Author : Andrew ML Lever, Kuan-Teh Jeang & Ben Berkhout
Published in : World Scientific Publishing
ISBN : 981-4295-30-2
File Type : pdf
File Size : 5 mb
Language : English
Published in : World Scientific Publishing
ISBN : 981-4295-30-2
File Type : pdf
File Size : 5 mb
Language : English
Description
Hematopoiesis is the process by which hematopoietic stem cells (HSCs) give rise to all the cellular components of the hematopoietic system. HSCs have the potential to proliferate indefinitely, and can differentiate into mature hematopoietic lineage-specific cells. The bone marrow is the principal site for hematopoiesis in adults. HSCs proliferate within the bone marrow and differentiate to produce the requisite number of highly specialized cells of the hematopoietic system. HSCs give rise to two different populations of cells: (1) a common lymphoid progenitor (CLP) population, that generates B cells, T cells and NK lineage cells; and (2) a common myeloid progenitor (CMP) population that generates granulocytes, neutrophils, eosinophils, macrophages and erythrocytes.
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