Recent Advances in Human Retroviruses Principles of Replication and Pathogenesis

Author : Andrew ML Lever, Kuan-Teh Jeang & Ben Berkhout

Published in : World Scientific Publishing 

ISBN : 981-4295-30-2

File Type : pdf

File Size : 5 mb

Language : English

Description

Hematopoiesis is the process by which hematopoietic stem cells (HSCs) give rise to all the cellular components of the hematopoietic system. HSCs have the potential to proliferate indefinitely, and can differentiate into mature hematopoietic lineage-specific cells. The bone marrow is the principal site for hematopoiesis in adults. HSCs proliferate within the bone marrow and differentiate to produce the requisite number of highly specialized cells of the hematopoietic system. HSCs give rise to two different populations of cells: (1) a common lymphoid progenitor (CLP) population, that generates B cells, T cells and NK lineage cells; and (2) a common myeloid progenitor (CMP) population that generates granulocytes, neutrophils, eosinophils, macrophages and erythrocytes.
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