ACS CHEMICAL BIOLOGY: VOLUME 5, ISSUE 2

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FILE TYPE : zip ( in under pdf )


JOURNAL TITLE : ACS Chemical Biology


LANGUAGE : ENGLISH


ISSUE DATE : 19 FEB 2010


pages : 149 - 254

DESCRIPTION

In this issue, Beld et al. (DOI: 10.1021/cb9002688) show that small-molecule diselenides catalyze oxidative protein folding in bacteria. The formation of a stabilizing disulfide bond in a flagellar protein is required for proper flagella assembly, and E. coli cells lacking the general protein oxidase DsbA are non-motile. In contrast to disulfides, small amounts of exogenously added diselenide restore motility, and cells swim to the edge of soft agar plates.
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