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JOURNAL TITLE : ACS Chemical Biology
LANGUAGE : ENGLISH
ISSUE DATE : 19 FEB 2010
pages : 149 - 254
DESCRIPTION
In this issue, Beld et al. (DOI: 10.1021/cb9002688) show that small-molecule diselenides catalyze oxidative protein folding in bacteria. The formation of a stabilizing disulfide bond in a flagellar protein is required for proper flagella assembly, and E. coli cells lacking the general protein oxidase DsbA are non-motile. In contrast to disulfides, small amounts of exogenously added diselenide restore motility, and cells swim to the edge of soft agar plates.
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