Cell Biology 3rd Edition (PDF)

Cell Biology 3rd Edition (PDF)
Author: Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz & Graham T. Johnson
Release at: 2017
Pages: 900
Edition: 3rd Edition
File Size: 97 MB
File Type: PDF
Language: English

Description of Cell Biology 3rd Edition (PDF)

Cell Biology 3rd Edition by T. D. Pollard, W. C. Earnshaw, Jennifer Lippincott-Schwartz & G. T. Johnson is a great book, available in PDF download. Our goal is to explain the molecular basis of life at the cellular level. We use evolution and molecular structures to provide the context for understanding the dynamic mechanisms that support life. As research in cell biology advances quickly, the field may appear to grow more complex, but we aim to show that understanding cells actually becomes simpler as new general principles emerge and more precise molecular mechanisms replace vague concepts about biological processes. For this edition, we revised the entire book, taking the reader to the frontiers of knowledge with exciting new information on every topic. We start with new insights about the evolution of eukaryotes, followed by macromolecules and research methods, including recent breakthroughs in light and electron microscopy. We begin the main part of the book with a section on basic molecular biology before sections on membranes, organelles, membrane traffic, signaling, adhesion and extracellular matrix, and cytoskeleton and cellular motility. As in the first two editions, we conclude with a comprehensive section on the cell cycle, which integrates all of the other topics.

Our coverage of most topics begins with an introduction to the molecular hardware and finishes with an account of how the various molecules function together in physiological systems. This organization allows for a clearer exposition of the general principles of each class of molecules, since they are treated as a group rather than isolated examples for each biological system. This approach allows us to present the operation of complex processes, such as signaling pathways, as an integrated whole, without diversions to introduce the various components as they appear along the pathway. For example, the section on signaling mechanisms begins with chapters on receptors, cytoplasmic signal transduction proteins, and second messengers, so the reader is prepared to appreciate the dynamics of 10 critical signaling systems in the chapter that concludes thesection. Teachers of shorter courses may concentrate on a subset of the examples in these systems chapters, or they may use parts of the “hardware” chapters as reference material.

The book emphasizes molecular mechanisms because they reveal the general principles of cellular function. As a further demonstration of this generality, we use a wide range of experimental organisms and specialized cells and tissues of vertebrate animals to illustrate these general principles. We also use medical “experiments of nature” to illustrate physiological functions throughout the book, since connections have now been made between most cellular systems and disease. The chapters on cellular functions integrate material on specialized cells and tissues. Epithelia, for example, are covered under membrane physiology and junctions; excitable membranes of neurons and muscle under membrane physiology; connective tissues under the extracellular matrix; the immune system under connective tissue cells, apoptosis, and signal transduction; muscle under the cytoskeleton and cell motility; and stem cells and cancer under the cell cycle and signal transduction.

Content of Cell Biology 3rd Edition (PDF)

SECTION I: Introduction to Cell Biology

Chapter 1: Introduction to Cells

Chapter 2: Evolution of Life on Earth

SECTION II: Chemical and Physical Background

Chapter 3: Molecules: Structures and Dynamics

Chapter 4: Biophysical Principles

Chapter 5: Macromolecular Assembly

Chapter 6: Research Strategies

SECTION III: Chromatin, Chromosomes, and the Cell Nucleus

Chapter 7: Chromosome Organization

Chapter 8: DNA Packaging in Chromatin and Chromosomes

Chapter 9: Nuclear Structure and Dynamics

SECTION IV: Central Dogma: From Gene to Protein

Chapter 10: Gene Expression

Chapter 11: Eukaryotic RNA Processing

Chapter 12: Protein Synthesis and Folding

SECTION V: Membrane Structure and Function

Chapter 13: Membrane Structure and Dynamics

Chapter 14: Membrane Pumps

Chapter 15: Membrane Carriers

Chapter 16: Membrane Channels

Chapter 17: Membrane Physiology

SECTION VI: Cellular Organelles and Membrane Trafficking

Chapter 18: Posttranslational Targeting of Proteins

Chapter 19: Mitochondria, Chloroplasts, Peroxisomes

Chapter 20: Endoplasmic Reticulum

Chapter 21: Secretory Membrane System and Golgi Apparatus

Chapter 22: Endocytosis and the Endosomal Membrane System

Chapter 23: Processing and Degradation of Cellular Components

SECTION VII: Signaling Mechanisms

Chapter 24: Plasma Membrane Receptors

Chapter 25: Protein Hardware for Signaling

Chapter 26: Second Messengers

Chapter 27: Integration of Signals

SECTION VIII: Cellular Adhesion and the Extracellular Matrix

Chapter 28: Cells of the Extracellular Matrix and Immune System

Chapter 29: Extracellular Matrix Molecules

Chapter 30: Cellular Adhesion

Chapter 31: Intercellular Junctions

Chapter 32: Connective Tissues

SECTION IX: Cytoskeleton and Cellular Motility

Chapter 33: Actin and Actin-Binding Proteins

Chapter 34: Microtubules and Centrosomes

Chapter 35: Intermediate Filaments

Chapter 36: Motor Proteins

Chapter 37: Intracellular Motility

Chapter 38: Cellular Motility

Chapter 39: Muscles

SECTION X: Cell Cycle

Chapter 40: Introduction to the Cell Cycle

Chapter 41: G1 Phase and Regulation of Cell Proliferation

Chapter 42: S Phase and DNA Replication

Chapter 43: G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis

Chapter 44: Mitosis and Cytokinesis

Chapter 45: Meiosis

Chapter 46: Programmed Cell Death




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