| Author: | Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz & Graham T. Johnson |
| Release at: | 2017 |
| Pages: | 900 |
| Edition: | 3rd Edition |
| File Size: | 97 MB |
| File Type: | |
| Language: | English |
Description of Cell Biology 3rd Edition (PDF)
Cell Biology 3rd Edition by T. D. Pollard, W. C. Earnshaw, Jennifer Lippincott-Schwartz & G. T. Johnson is a great book, available in PDF download. Our goal is to explain the molecular basis of life at the cellular level. We use evolution and molecular structures to provide the context for understanding the dynamic mechanisms that support life. As research in cell biology advances quickly, the field may appear to grow more complex, but we aim to show that understanding cells actually becomes simpler as new general principles emerge and more precise molecular mechanisms replace vague concepts about biological processes. For this edition, we revised the entire book, taking the reader to the frontiers of knowledge with exciting new information on every topic. We start with new insights about the evolution of eukaryotes, followed by macromolecules and research methods, including recent breakthroughs in light and electron microscopy. We begin the main part of the book with a section on basic molecular biology before sections on membranes, organelles, membrane traffic, signaling, adhesion and extracellular matrix, and cytoskeleton and cellular motility. As in the first two editions, we conclude with a comprehensive section on the cell cycle, which integrates all of the other topics.
Our coverage of most topics begins with an introduction to the molecular hardware and finishes with an account of how the various molecules function together in physiological systems. This organization allows for a clearer exposition of the general principles of each class of molecules, since they are treated as a group rather than isolated examples for each biological system. This approach allows us to present the operation of complex processes, such as signaling pathways, as an integrated whole, without diversions to introduce the various components as they appear along the pathway. For example, the section on signaling mechanisms begins with chapters on receptors, cytoplasmic signal transduction proteins, and second messengers, so the reader is prepared to appreciate the dynamics of 10 critical signaling systems in the chapter that concludes thesection. Teachers of shorter courses may concentrate on a subset of the examples in these systems chapters, or they may use parts of the “hardware” chapters as reference material.
The book emphasizes molecular mechanisms because they reveal the general principles of cellular function. As a further demonstration of this generality, we use a wide range of experimental organisms and specialized cells and tissues of vertebrate animals to illustrate these general principles. We also use medical “experiments of nature” to illustrate physiological functions throughout the book, since connections have now been made between most cellular systems and disease. The chapters on cellular functions integrate material on specialized cells and tissues. Epithelia, for example, are covered under membrane physiology and junctions; excitable membranes of neurons and muscle under membrane physiology; connective tissues under the extracellular matrix; the immune system under connective tissue cells, apoptosis, and signal transduction; muscle under the cytoskeleton and cell motility; and stem cells and cancer under the cell cycle and signal transduction.
Content of Cell Biology 3rd Edition (PDF)
SECTION I: Introduction to Cell Biology
Chapter 1: Introduction to Cells
Chapter 2: Evolution of Life on Earth
SECTION II: Chemical and Physical Background
Chapter 3: Molecules: Structures and Dynamics
Chapter 4: Biophysical Principles
Chapter 5: Macromolecular Assembly
Chapter 6: Research Strategies
SECTION III: Chromatin, Chromosomes, and the Cell Nucleus
Chapter 7: Chromosome Organization
Chapter 8: DNA Packaging in Chromatin and Chromosomes
Chapter 9: Nuclear Structure and Dynamics
SECTION IV: Central Dogma: From Gene to Protein
Chapter 10: Gene Expression
Chapter 11: Eukaryotic RNA Processing
Chapter 12: Protein Synthesis and Folding
SECTION V: Membrane Structure and Function
Chapter 13: Membrane Structure and Dynamics
Chapter 14: Membrane Pumps
Chapter 15: Membrane Carriers
Chapter 16: Membrane Channels
Chapter 17: Membrane Physiology
SECTION VI: Cellular Organelles and Membrane Trafficking
Chapter 18: Posttranslational Targeting of Proteins
Chapter 19: Mitochondria, Chloroplasts, Peroxisomes
Chapter 20: Endoplasmic Reticulum
Chapter 21: Secretory Membrane System and Golgi Apparatus
Chapter 22: Endocytosis and the Endosomal Membrane System
Chapter 23: Processing and Degradation of Cellular Components
SECTION VII: Signaling Mechanisms
Chapter 24: Plasma Membrane Receptors
Chapter 25: Protein Hardware for Signaling
Chapter 26: Second Messengers
Chapter 27: Integration of Signals
SECTION VIII: Cellular Adhesion and the Extracellular Matrix
Chapter 28: Cells of the Extracellular Matrix and Immune System
Chapter 29: Extracellular Matrix Molecules
Chapter 30: Cellular Adhesion
Chapter 31: Intercellular Junctions
Chapter 32: Connective Tissues
SECTION IX: Cytoskeleton and Cellular Motility
Chapter 33: Actin and Actin-Binding Proteins
Chapter 34: Microtubules and Centrosomes
Chapter 35: Intermediate Filaments
Chapter 36: Motor Proteins
Chapter 37: Intracellular Motility
Chapter 38: Cellular Motility
Chapter 39: Muscles
SECTION X: Cell Cycle
Chapter 40: Introduction to the Cell Cycle
Chapter 41: G1 Phase and Regulation of Cell Proliferation
Chapter 42: S Phase and DNA Replication
Chapter 43: G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis
Chapter 44: Mitosis and Cytokinesis
Chapter 45: Meiosis
Chapter 46: Programmed Cell Death
Glossary
Index
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