Genetics Principles and Analysis

Genetics Principles and Analysis

Daniel L. Hartl & Elizabeth W. Jones
Published in: Jones and Bartlett Publishers
Release Year: 1998
ISBN: 0-7637-0489-X
Pages: 1367
Edition: Fourth Edition
File Size: 25 MB
File Type: pdf
Language: English

Description of Genetics Principles and Analysis

This book is titled Genetics: Principles and Analysis, Fourth Edition because it embodies our belief that a good course in genetics should maintain the right balance between two important aspects of the science. The first aspect is that genetics is a body of knowledge pertaining to genetic transmission, function, and mutation. This constitutes the Principles. The second aspect is that genetics is an experimental approach, or a kit of "tools," for the study of biological processes such as development or behavior. This is Analysis.
The overall aim of Genetics: Principles and Analysis, Fourth Edition, is to provide a clear, comprehensive, rigorous, and balanced introduction to genetics at the college level. It is a guide to learning a critically important and sometimes difficult subject. 
The rationale of the book is that any student claiming knowledge of genetics must:
• Understand the basic processes of gene transmission, mutation, expression, and regulation;
• Be able to think like a geneticist at the elementary level of being able to formulate genetic hypotheses, work out their consequences, and test the results against observed data;
• Be able to solve problems of several types, including problems that ask the student to verbalize genetic principles in his or her own words, single-concept exercises that require application of definitions or the basic principles of genetics, genetic analysis in which several concepts must be applied in logical order, and quantitative problems that call for some numerical calculation;
• Gain some sense of the social and historical context in which genetics has developed and is continuing to develop; and
• Have some familiarity with the genetic resources and information that are available through the Internet.
Genetics: Principles and Analysis, Fourth Edition, incorporates many special features to help students achieve these learning goals. The text is clearly and concisely written in a somewhat relaxed prose style without being chummy or excessively familiar. Each chapter is headed by a list of Principles that are related at numerous points to the larger whole. Each chapter contains two or three Connections in which the text material is connected to excerpts of classic papers that report key experiments in genetics or that raise important social, ethical, or legal issues in genetics. Each Connection has a brief introduction of its own, explaining the importance of the experiment and the historical context in which it was carried out. At the end of each chapter is a complete Summary, Key Terms, GeNETics on the web exercises that guide students in the use of Internet resources in genetics, and several different types and levels of Problems. These features are discussed individually below.
In recent decades, both the amount of genetic knowledge and its rate of growth have exploded. Many of the new discoveries have personal and social relevance through applications of genetics to human affairs in prenatal diagnosis, testing for carriers, and identification of genetic risk factors for complex traits, such as breast cancer and heart disease. There are also ethical controversies: Should genetic manipulation be used on patients for the treatment of the disease? Should human fetuses be used in research? Should human beings be cloned? There are also social controversies—for example when insurance companies exclude coverage of people because of their inherited risks of certain diseases.
Inspired in part by the controversies and the publicity, many of today's students come to a course in genetics with great enthusiasm. The challenges for the teacher are:
• To sustain this enthusiasm;
• To help motivate a desire to understand the principles of genetics in a comprehensive and rigorous way;
• To guide students in gaining an understanding that genetics is not only a set of principles but also an experimental approach to solving a wide range of biological problems; and
• To help students learn to think about genetic problems and about the wider social and ethical issues arising from genetics.
While addressing these challenges in Principles and Analysis, we have also tried to show the beauty, logical clarity, and unity of the subject. Endlessly fascinating, genetics is the material basis of the
continuity of life.

Content of Genetics Principles and Analysis

Chapter 1
The Molecular Basis of Heredity and Variation

Chapter 2
Principles of Genetic Transmission

Chapter 3
Genes and Chromosomes

Chapter 4
Genetic Linkage and Chromosome Mapping

Chapter 5
The Molecular Structure and Replication of the Genetic Material

Chapter 6
The Molecular Organization of Chromosomes

Chapter 7
Variation in Chromosome Number and Structure

Chapter 8
The Genetics of Bacteria and Viruses

Chapter 9
Genetic Engineering and Genome Analysis

Chapter 10
Gene Expression

Chapter 11
Regulation of Gene Activity

Chapter 12
The Genetic Control of Development

Chapter 13
Mutation, DNA Repair, and Recombination

Chapter 14
Extranuclear Inheritance

Chapter 15
Population Genetics and Evolution

Chapter 16
Quantitative Genetics and Multifactorial Inheritance

Chapter 17
Genetics of Biorhythms and Behavior.
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