| Author: |
Jin Xie & Chengjian Zhu
|
| Published in: | Springer |
| Release Year: | 2016 |
| ISBN: | 978-3-662-49496-7 |
| Pages: | 91 |
| Edition: | Green chemistry for sustainability |
| File Size: | 6 MB |
| File Type: | |
| Language: | English |
Description of Sustainable C(sp3)-H Bond Functionalization
Most references in the Sustainable C(sp3)-H Bond Functionalization book have been published in the recent 5 years. They will bring us a new chance to review the relevant progress of C(sp3)-H bond functionalization and also offer a new research direction. In Chap. 1, we introduce the transition-metal-catalyzed unactivated C(sp3)-H bond functionalization using different directing functional groups.
Content of Sustainable C(sp3)-H Bond Functionalization
1 Transition Metal-Catalyzed, Directing Group-Assisted C(sp3)–H Bond Functionalization 1
1.1 Introduction 1
1.2 Directed C(sp3)–H Arylation 2
1.3 Directed C(sp3)–H Alkynylation, Alkenylation, and Alkylation 12
1.4 Directed C–X Bond Forming from C(sp3)–H Bond 16
1.5 Conclusions 20
References. 21
2 Recent Advances in Non-Directed C(sp3)–H Bond
Functionalization 25
2.1 Introduction 25
2.2 Oxidative Functionalization of α-C(sp3)–H Bond Adjacent to Nitrogen Atoms . 26
2.3 Oxidative Functionalization of α-C(sp3)–H Bond Adjacent to Oxygen Atom 31
2.4 Oxidative Functionalization of Allylic and Benzylic C(sp3)–H Bond. 37
2.5 Oxidative Functionalization of General C(sp3)–H Bond 43
2.6 Redox-Neutral C(sp3)–H Bond Functionalization. 50
2.6.1 1,n–H Shift-Induced C(sp3)–H Bond Functionalization. 51
2.6.2 Metal-Carbenoid-Induced C(sp3)–H Bond Functionalization 51
2.6.3 Metalation-Induced Arylation of C(sp3)–H Bond 52
2.7 Conclusions 53
References. 53
3 Functionalization of C(sp3)–H Bond by Visible-Light Photoredox Catalysis 61
3.1 Introduction 61
3.2 α-C(sp3)–H Bond Functionalization of Amines 63
3.3 α-C(sp3)–H Functionalization of Ethers and Alcohols. 72
3.4 Selective Functionalization of Unactivated C(sp3)–H Bond 75
3.5 Conclusions 79
References. 80
1.1 Introduction 1
1.2 Directed C(sp3)–H Arylation 2
1.3 Directed C(sp3)–H Alkynylation, Alkenylation, and Alkylation 12
1.4 Directed C–X Bond Forming from C(sp3)–H Bond 16
1.5 Conclusions 20
References. 21
2 Recent Advances in Non-Directed C(sp3)–H Bond
Functionalization 25
2.1 Introduction 25
2.2 Oxidative Functionalization of α-C(sp3)–H Bond Adjacent to Nitrogen Atoms . 26
2.3 Oxidative Functionalization of α-C(sp3)–H Bond Adjacent to Oxygen Atom 31
2.4 Oxidative Functionalization of Allylic and Benzylic C(sp3)–H Bond. 37
2.5 Oxidative Functionalization of General C(sp3)–H Bond 43
2.6 Redox-Neutral C(sp3)–H Bond Functionalization. 50
2.6.1 1,n–H Shift-Induced C(sp3)–H Bond Functionalization. 51
2.6.2 Metal-Carbenoid-Induced C(sp3)–H Bond Functionalization 51
2.6.3 Metalation-Induced Arylation of C(sp3)–H Bond 52
2.7 Conclusions 53
References. 53
3 Functionalization of C(sp3)–H Bond by Visible-Light Photoredox Catalysis 61
3.1 Introduction 61
3.2 α-C(sp3)–H Bond Functionalization of Amines 63
3.3 α-C(sp3)–H Functionalization of Ethers and Alcohols. 72
3.4 Selective Functionalization of Unactivated C(sp3)–H Bond 75
3.5 Conclusions 79
References. 80
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