Function and Control of the Spx-Family of Proteins Within the Bacterial Stress Response

Bacterial Stress
 
Author:
Peter Zuber
Publisher:
Springer
ISBN No: 978-1-4614-6925-4
Release at: 2013
Pages: 53
Edition:
First Edition
File Size: 1 MB
File Type: pdf
Language: English



Description of Function and Control of the Spx-Family of Proteins Within the Bacterial Stress Response


A complex regulatory network governs the microbial response to encounters with harsh environmental conditions. Such networks also influence essential decisionmaking processes that coordinate metabolic pathways and maintain cellular ultrastructure. 

The study of such networks has been a fruitful area of research over the years and continues to be a major focus of biomedical, applied, and environmental studies. Investigations using model bacterial systems revealed conserved mechanisms that neutralize harmful conditions by destroying toxic agents or alleviating their damaging effects.

Content of Function and Control of the Spx-Family of Proteins Within the Bacterial Stress Response



Function and Control of the Spx-Family of Proteins

Within the Bacterial Stress Response 1

Introduction 1

An Overview of Spx  2

Regulation of the Stress Response in Gram-Positive Bacteria. 5

Control Within Complex Developmental Programs and the Negative Impact of Spx 6

Quorum-Sensing Control of Competence Development and Virulence in Firmicutes  8

Cell Envelope Stress Response Systems that Promote spx Expression  10

Oxidative Stress Response  12

General Stress Response Through Activation of σB and Involvement of Spx Paralogs  14

Expression of spx is Affected by Multiple Stress Stimuli  17

Post-Transcriptional Control of Spx: Redox-Dependent Activation  22

Post-Transcriptional Control of Spx: Regulated Proteolysis 24

Targets of Spx-Dependent Transcriptional Activation 27

Spx Function and Bacterial Virulence 30

Questions and Future Directions  31

References. 37

Index 47

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