In Vitro Toxicology Systems

 

Author:	Anna Bal-Price & Paul Jennings
Release at:	2014
Pages:	607
Edition:	First Edition
File Size:	11 MB
File Type:	pdf
Language:	English

Description of In Vitro Toxicology Systems

In this In Vitro Toxicology Systems by Paul book, we attempt to bring together the important issues and considerations we believe are needed in order to develop a workable, reliable, The replacement of animals in toxicity testing regimes by integrated testing strategy.

We begin the In Vitro Toxicology Systems book with a review on The chemical risk assessment by Alice Limonciel. Alice Limonciel describes the history of the development of chemical testing and the evolution of chemical regulation. This process has had several key milestones. Among them were Elixir Sulfanilamide in 1937 and the thalidomide disaster in the late 1950s and early 1960s. 

The unfortunate use of the solvent diethylene glycol in Elixir Sulfanilamide caused the deaths of over a hundred people due to acute renal failure and introduced regulations where proof of safety of a compound was required to be shown before marketing. The thalidomide disaster introduced the necessity to test for reproductive toxicity. It is perhaps not surprising that these two examples were pharmaceuticals.

Content of In Vitro Toxicology Systems

PART I INTRODUCTION

1 The Past, Present, and Future of Chemical Risk Assessment 3
Alice Limonciel

PART II SYSTEMIC ORGAN TOXICITY

2 In Vitro Systems for Hepatotoxicity Testing  27
Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab,
Raymond Reif,and Patricio Godoy
3 In Vitro Methods for Cardiotoxicity Testing  45
Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou,
Jürgen Hescheler,and Agapios Sachinidis
4 Renal Cell Culture. 79
Paul Jennings, Lydia Aschauer, Anja Wilmes,
and Gerhard Gstraunthaler
5 Cellular Models for In Vitro Lung Toxicology. 103
Oliver H. Wittekindt

PART III NEUROTOXICITY

6 In Vitro Developmental Neurotoxicity Testing:
Relevant Models and Endpoints  125
Anna Bal-Priceand Helena T. Hogberg
7 Blood–Brain Barrier In Vitro Models and Their Applications
in Toxicology . 147
Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck,
Emmanuel Sevin, Marie-Pierre Dehouck, Roméo Cecchelli,
and Maxime Culot

PART IV SENSORY ORGAN MODELS

8 Ocular Toxicity 169
Chantra Eskes, Erwin van Vliet, Michael Schäffer,and Valérie Zuang
9 In Vitro Models for Ototoxic Research 199
Jochen Schachtand Michael G. Leitner

PART V OTHER ORGANS AND ASPECTS

10 Dermal Toxicity: Skin Sensitization . 225
David Basketterand Silvia Casati
11 Immunotoxicity 241
Thomas Hartung
12 Reproductive Toxicity  269
Giovanna Lazzariand Cesare Galli
13 Evaluating Endocrine Disruption In Vitro 285
Patrick J. Devine
14 Current and Emerging In Vitro Methods for Genotoxicity
and Carcinogenicity307
Federica Madia, Pascal Phrakonkham,and Raffaella Corvi

PART VI THE USE OF STEM CELLS

15 Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening . 335
Caroline Rauch, Paul Jennings,and Anja Wilmes
16 Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental
Toxicity Testing 351
Ellen Fritsche

PART VII TECHNIQUES AND MARKERS

17 High Content Imaging Approaches for In Vitro Toxicology 377
Marianne Uteng, Davide Germano, Kamal Kumar Balavenkatraman,
Francois Pognan,and Armin Wolf
18 Application of “Omics” Technologies to In Vitro Toxicology. 399
Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits,
Tanja Waldmann, Liang Zhao, Helena T. Hogberg,
and Erwin van Vliet
19 Stress Response Pathways 433
Martin O. Leonard, Alice Limonciel,and Paul Jennings
20 Translational Biomarkers, In Vitro and In Vivo 459
Anja Wilmes, Alice Limonciel, Martin O. Leonard,and Paul Jennings

PART VIII CHALLENGES AND CONSIDERATIONS

21 Nanotoxicology 481
Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti,
and François Rossi
22 Consideration of Metabolism in In Vitro Cellular Systems501
Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola,
and Miia Turpeinen
23 In Vitro Approaches to Predictive Biokinetics . 521
Bas J. Blaauboer
24 Extrapolating In Vitro Results to Predict Human Toxicity531
Nadia Quignot, Jérémy Hamon,and Frederic Y. Bois
25 Considerations in the Development of In Vitro Toxicity
Testing Methods Intended for Regulatory Use 551
Sandra Coecke, Gerard Bowe, Anne Milcamps, Camilla Bernasconi,
Ann-Charlotte Bostroem, Gilles Bories, Salvador Fortaner,
Jean-Michel Gineste, Varvara Gouliarmou, Ingrid Langezaal,
Roman Liska, Emilio Mendoza, Siegfried Morath, Vittorio Reina,
Iwona Wilk-Zasadna,and Maurice Whelan
Index 571

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