Metabolism and Bacterial Pathogenesis

Metabolism and Bacterial Pathogenesis
Tyrrell Conway & Paul Cohen
Publisher: ASM Press
Release at: 2015
Pages: 395
First Edition
File Size: 17 MB
File Type: pdf
Language: English

Description of Metabolism and Bacterial Pathogenesis

Further considered this concept to apply equally to bacterial commensals and pathogens. He considered a nutrient acquisition to be as critical for the success of a bacterial pathogen in its host as its ability to produce virulence factors. Despite the general acceptance of Frater's ideas, until recently, metabolism and bacterial pathogenesis were considered to be two distinctly different fields of study. Even the title of this book: Metabolism and Bacterial Pathogenesis might be interpreted as meaning that these fields are separate entities. 

Nothing could be further from the truth. There is no doubt that the discovery of pathogen-specific virulence factors such as fimbriae that allow adhesion to mucosal surface receptors, secreted toxins, iron acquisition systems, motility, mechanisms geared to avoid immune responses, etc., have been instrumental in understanding bacterial pathogenesis and in some instances in devising ways to interfere with the pathogenic process.

Content of Metabolism and Bacterial Pathogenesis

1 Glycolysis for the Microbiome Generation 1
Alan J. Wolfe

2 Pathogenesis - Thoughts from the Front Line 17
James P. Nataro

3 Metabolic Adaptations of Intracellular Bacterial Pathogens and their Mammalian Hos Cells during Infection (“Pathometabolism”) 27
Wolfgang Eisenreich, Jürgen Heesemann, Thomas Rudel, and Werner Goebel

4 Small RNAs Regulate Primary and Secondary Metabolism in Gram-negative Bacteria 59
Maksym Bobrovskyy, Carin K. Vanderpool, and Gregory R. Richards

5 Sialic acid and N-acetylglucosamine Regulate type 1 Fimbriae Synthesis 95
Ian C. Blomfield

6 Trigger Enzymes: Coordination of Metabolism and Virulence Gene Expression 105
Fabian Commichau and Jörg Stülke

7 Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria 129
Anthony R. Richardson, Greg A. Somerville, and Abraham L. Sonenshein

8 Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle 167
Arianna Corona and Ira Schwartz

9 Metabolism and Pathogenicity of Pseudomonas aeruginosa Infections in the Lungs of Individuals with Cystic Fibrosis 185
Gregory C. Palmer and Marvin Whiteley

10 Metabolism and Fitness of Urinary Tract Pathogens 215
Christopher J. Alteri and Harry L.T. Mobley

11 Bacterial Metabolism in the Host Environment: Pathogen Growth and Nutrient Assimilation in the Mammalian Upper Respiratory Tract 231
Sandra K. Armstrong

12 Saliva as the Sole Nutritional Source in the Development of Multispecies Communities in Dental Plaque 263
Nicholas S. Jakubovics

13 Enteric Pathogens Exploit the Microbiota-generated Nutritional Environment of the Gut 279
Alline R. Pacheco and Vanessa Sperandio

14 The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection 297
Bärbel Stecher

15 Host Sialic Acids: A Delicacy for the Pathogen with Discerning Taste 321
B.L. Haines-Menges, W.B. Whitaker, J.B. Lubin, and E. Fidelma Boyd

16 Commensal and Pathogenic Escherichia coli Metabolism in the Gut 343
Tyrrell Conway and Paul S. Cohen

Index 363

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