| Author: |
Arkaitz Correa
|
| Release at: | 2016 |
| Pages: | 342 |
| Edition: |
First Edition
|
| File Size: | 17 MB |
| File Type: | |
| Language: | English |
Description of Ni and Fe-Based Cross-Coupling Reactions (PDF)
Ni and Fe-Based Cross-Coupling Reactions written by Arkaitz Correan is a great Chemistry book available for (PDF) download. The genesis of cross-coupling reactions is often traced back to Ni-catalyzed reactions of Grignard reagents with aryl or vinyl halides reported in the 1970s. However, earlier reports by Kharasch in the 1940s already demonstrated the ability of simple iron salts to act as catalysts in couplings involving Grignard reagents. Unfortunately, these Fe and Ni-catalyzed processes were overshadowed by the meteoric development of palladium chemistry discovered shortly thereafter. Despite the undeniable maturity of Pd-based processes, the recent years have witnessed a renaissance in Fe and Ni-catalyzed reactions providing new dogmas for achieving practical and unconventional bond disconnections that were beyond reach using classical Pd regimes. Consequently, cross-coupling reactions have impressively evolved from standard laboratory procedures into indispensable and routine techniques in chemical industry. As an illustrative example of the high value and tremendous impact of these chemical processes, the Nobel Prize in Chemistry 2010 was awarded jointly to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki for their important discoveries in palladium-catalyzed cross-coupling reactions.
Unlike palladium, iron and nickel can adopt a broad spectrum of oxidation states, thus allowing different modes of reactivity and radical mechanisms. Likewise, thelow cost of nickel and environmentally friendly character of iron make them privileged catalysts from the standpoints of economics and sustainability. This topical collection aims to cover recent developments in nickel and iron-based cross-couplings and illustrate how the intrinsic and unique properties of those first-row metals have enabled their use as convenient and highly versatile catalysts for a myriad of unprecedented, yet intriguing, chemical transformations.
Content of Ni and Fe-Based Cross-Coupling Reactions (PDF)
Chapter 1: Ni-Catalyzed C–C Couplings Using Alkyl Electrophiles
Chapter 2: Photoredox Catalysis in Nickel-Catalyzed Cross-Coupling
Chapter 3: Nickel-Catalyzed Reductive Couplings
Chapter 4: Ni- and Fe-catalyzed Carboxylation of Unsaturated Hydrocarbons with CO2
Chapter 5: Nickel-Catalyzed Cross-Coupling Reactions of Unreactive Phenolic Electrophiles via C–O Bond Activation
Chapter 6: Nickel-Catalyzed Aromatic C–H Functionalization
Chapter 7: Iron-Catalyzed C–H Functionalization Processes
Chapter 8: Fe-Catalyzed Cross-Dehydrogenative Coupling Reactions
Chapter 9: Iron-Catalyzed C–C Cross-Couplings Using Organometallics
Index
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