Description of Classical Electrodynamics 3rd Edition
Oncogenes 2nd Edition written by Geoffrey M. Cooper is a great Cancer Biology book available for (PDF) download. Work in a large number of laboratories has led to the realization that the development of cancer is a consequence of abnormal expression or function of specific cellular genesoncogenes and tumor suppressor genes. Oncogenes are mutated forms of normal cell genes (called proto-oncogenes) that stimulate cell proliferation. Tumor suppressor genes, on the other hand, normally inhibit cell proliferation, and it is their loss or inactivation in tumors that contributes to the unregulated growth of cancer cells. Proto-oncogenes and tumor suppressor genes are not only key to the development of cancer, but they also play
central roles in regulatory systems governing the proliferation and differentiation of normal cells. Consequently, understanding oncogenes and tumor suppressor genes not only is important from the standpoint of cancer, but has become a key area for students and scientists interested in diverse aspects of biology and medicine.
This Oncogenes 2nd Edition book is intended to serve the needs of advanced undergraduates, medical students, graduate students, physicians, and scientists by providing an introduction and broad overview of the oncogene/tumor suppressor gene field. As in the first edition, the approach I have taken throughout the book is to describe the key experiments that led to our current thinking, and then to summarize the results of subsequent studies within this framework. In so doing, I have frequently indicated the dates of key discoveries and the names of the scientists. My intent in doing this is to impart to the reader a flavor of the way in which work in this field has progressed, and of the large number of researchers who have made important contributions.
Content of Oncogenes 2nd Edition (PDF)
Part I: Introduction
Chapter 1: Introduction to Electrostatics
The Cancer Cell
Biology of Human Cancers
Experimental Induction of Cancer in Animals
Growth of Cells in Culture
Growth Control and the Cell Cycle
Cell Transformation in Vitro
Biochemical Alterations in Transformed Cells
Summary
Part: II Viral Oncogenes
Chapter 2: Tumor Viruses
Hepatitis B Viruses
Simian Virus 40 and Polyomavirus
Papillomaviruses
Adenoviruses
Herpesviruses
Poxviruses
Retroviruses
Summary
Chapter 3: Retroviral Oncogenes
The src Gene of RSV
The RSV and ALV Genomes
Other Retroviral Oncogenes
Summary
Chapter 4: The Origin of Retroviral Oncogenes
Isolation of Acutely Transforming Retroviruses
Normal Cell Homologs of Retroviral Oncogenes
Structure and Expression of Proto-oncogenes
Capture of Proto-oncogenes by Retroviruses
Viral Oncogenes are Altered Versions of Proto-oncogenes
Summary
Part: III Cellular Oncogenes and Tumor Suppressor Genes
Chapter 5: Identification of Cellular Oncogenes by Gene Transfer
Transformation by Cellular DNA
Oncogenes of Human Tumors
Human Tumor Oncogenes and the ras Family
Mechanism of ras Oncogene Activation
Other Oncogenes Isolated by Gene Transfer
Summary
Chapter 6: Cellular Oncogene Targets for Retroviral Integration
Tumor Induction by Retroviruses without Oncogenes
The Structure and Integration Sites of ALV Proviruses in Lymphomas
Activation of c-myc in Bursal Lymphomas
Activation of Other Proto-oncogenes by Insertional Mutagenesis
Identification of New Cellular Oncogenes as Targets for Insertional Mutagenesis
Summary
Chapter 7: Oncogenes and Chromosome Translocation
Chromosome Abnormalities in Neoplasms
Translocation of c-myc in Burkitt's Lymphomas and Plasmacytomas
The Philadelphia Translocation and abl
More TranslocationsMore Oncogenes
Summary
Chapter 8: Amplification of Oncogenes in Tumors
Gene Amplification and Chromosome Abnormalities
Amplification of c-myc
New Members of the myc Gene Family
Amplification of erbB and erbB-2
Other Amplified Oncogenes
Summary
Chapter 9: Retinoblastoma and the Discovery of Tumor Suppressor Genes
Somatic Cell Hybridization
Inherited and Sporadic Retinoblastoma
Mapping the Retinoblastoma Gene
The Retinoblastoma Gene is Recessive at the Cellular Level
Molecular Cloning of the Rb Gene
Role of the Rb Gene in Other Neoplasms
Summary
Chapter 10: Tumor Suppressor Genes in Human Neoplasms
The p53 Gene
Identification of Additional Tumor Suppressor Genes in Colorectal Carcinomas
Tumor Suppressor Genes in Other Inherited Cancers
Candidates for Additional Tumor Suppressors
Summary
Chapter 11: Role of Oncogenes and Tumor Suppressor Genes in the Pathogenesis of Neoplasms
Biological Activities of Oncogenes in Vitro
Induction of Neoplasms by Oncogenes in Vivo
Oncogenes and Tumor Suppressor Genes in Tumors Induced by Chemical Carcinogens
Oncogenes and Tumor Suppressor Genes in Development of Human Neoplasms
Summary
Part: IV Functions of Oncogenes and Tumor Suppressor Genes
Chapter 12: Oncogenes and Growth Factors
Platelet-Derived Growth Factor and the sis Oncogene
A Family of Oncogenes Related to Fibroblast Growth Factors
The wnt Gene Family
Transforming Activity of Epidermal Growth Factor and TGF-α
Hematopoietic Growth Factors as Oncogenes
Summary
Chapter 13: Protein-Tyrosine Kinases and Growth Factor Receptors
Lessons from Src: Protein-Tyrosine Kinases
Growth Factor Receptors: Protein-Tyrosine Kinases and Oncogenes
Nonreceptor Protein-Tyrosine Kinases
Oncogenes Derived from Nontyrosine Kinase Receptors
Summary
Chapter 14: Guanine Nucleotide Binding Proteins G Proteins
Similarities between Ras and the G Proteins
Proteins that Regulate Ras
Targets of Ras
Summary
Chapter 15: Protein-Serine/Threonine Kinases
The raf Oncogene Family
The Protein Kinase C Family
The mos Oncogene
Other Protein-Serine/Threonine Kinase Oncogenes
Summary
Chapter 16: Transcription Factors
Oncogenes and Steroid Hormone Receptors
The Jun and Fos Families: Components of Transcription Factor AP-1
The Myc Family
Other Oncogene Transcription Factors
Tumor Suppressor Gene Products
Summary
Chapter 17: Pathways of Mitogenic Signal Transduction
Receptor Tyrosine Kinases and Their Targets
Ras Activation
The Raf Protein-Serine/Threonine Kinase
The MAP Kinase Pathway
Transcription Factors and Alterations in Gene Expression
Summary
Chapter 18: Regulation of the Cell Cycle
Cyclins and Cyclin-Dependent Kinases
Cyclin D: A Proto-oncogene Inducible by Growth Factors
Cell Cycle Regulation of Rb
p53 and MTS1: Tumor Suppressors that Regulate Cdks
Role of p53 in Cell Cycle Arrest and Apoptosis Induced by DNA Damage
Summary
Chapter 19: Development, Differentiation, and Programmed Cell Death
Proto-oncogenes in Meiosis and Early Embryo Development
Role of the Ras/Raf Pathway in Development of Drosophila and C. elegans
Proto-oncogenes in Neuronal Differentiation
Developmental Roles of Other Proto-oncogenes
The bcl-2 Oncogene and Programmed Cell Death
Summary
Part: V Clinical Applications
Chapter 20: New Prospects for Cancer Prevention and Treatment
Identification of Individuals with Inherited Susceptibilities to Cancer
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