Oncogenes 2nd Edition by Geoffrey M. Cooper (PDF)


Geoffrey M. Cooper
Release at: 1995
Pages: 774
2nd Edition
File Size: 7 MB
File Type: pdf
Language: English

Description of Classical Electrodynamics 3rd Edition

Oncogenes 2nd Edition written by Geoffrey M. Cooper is a great Cancer Biology book available for (PDF) download. Work in a large number of laboratories has led to the realization that the development of cancer is a consequence of abnormal expression or function of specific cellular genesoncogenes and tumor suppressor genes. Oncogenes are mutated forms of normal cell genes (called proto-oncogenes) that stimulate cell proliferation. Tumor suppressor genes, on the other hand, normally inhibit cell proliferation, and it is their loss or inactivation in tumors that contributes to the unregulated growth of cancer cells. Proto-oncogenes and tumor suppressor genes are not only key to the development of cancer, but they also play central roles in regulatory systems governing the proliferation and differentiation of normal cells. Consequently, understanding oncogenes and tumor suppressor genes not only is important from the standpoint of cancer, but has become a key area for students and scientists interested in diverse aspects of biology and medicine.

This Oncogenes 2nd Edition book is intended to serve the needs of advanced undergraduates, medical students, graduate students, physicians, and scientists by providing an introduction and broad overview of the oncogene/tumor suppressor gene field. As in the first edition, the approach I have taken throughout the book is to describe the key experiments that led to our current thinking, and then to summarize the results of subsequent studies within this framework. In so doing, I have frequently indicated the dates of key discoveries and the names of the scientists. My intent in doing this is to impart to the reader a flavor of the way in which work in this field has progressed, and of the large number of researchers who have made important contributions.

Content of Oncogenes 2nd Edition (PDF)

Part I: Introduction

Chapter 1: Introduction to Electrostatics

  • The Cancer Cell
  • Biology of Human Cancers
  • Experimental Induction of Cancer in Animals
  • Growth of Cells in Culture
  • Growth Control and the Cell Cycle
  • Cell Transformation in Vitro
  • Biochemical Alterations in Transformed Cells
  • Summary
  • Part: II Viral Oncogenes

    Chapter 2: Tumor Viruses

  • Hepatitis B Viruses
  • Simian Virus 40 and Polyomavirus
  • Papillomaviruses
  • Adenoviruses
  • Herpesviruses
  • Poxviruses
  • Retroviruses
  • Summary
  • Chapter 3: Retroviral Oncogenes

  • The src Gene of RSV
  • The RSV and ALV Genomes
  • Other Retroviral Oncogenes
  • Summary
  • Chapter 4: The Origin of Retroviral Oncogenes

  • Isolation of Acutely Transforming Retroviruses
  • Normal Cell Homologs of Retroviral Oncogenes
  • Structure and Expression of Proto-oncogenes
  • Capture of Proto-oncogenes by Retroviruses
  • Viral Oncogenes are Altered Versions of Proto-oncogenes
  • Summary
  • Part: III Cellular Oncogenes and Tumor Suppressor Genes

    Chapter 5: Identification of Cellular Oncogenes by Gene Transfer

  • Transformation by Cellular DNA
  • Oncogenes of Human Tumors
  • Human Tumor Oncogenes and the ras Family
  • Mechanism of ras Oncogene Activation
  • Other Oncogenes Isolated by Gene Transfer
  • Summary
  • Chapter 6: Cellular Oncogene Targets for Retroviral Integration

  • Tumor Induction by Retroviruses without Oncogenes
  • The Structure and Integration Sites of ALV Proviruses in Lymphomas
  • Activation of c-myc in Bursal Lymphomas
  • Activation of Other Proto-oncogenes by Insertional Mutagenesis
  • Identification of New Cellular Oncogenes as Targets for Insertional Mutagenesis
  • Summary
  • Chapter 7: Oncogenes and Chromosome Translocation

  • Chromosome Abnormalities in Neoplasms
  • Translocation of c-myc in Burkitt's Lymphomas and Plasmacytomas
  • The Philadelphia Translocation and abl
  • More TranslocationsMore Oncogenes
  • Summary
  • Chapter 8: Amplification of Oncogenes in Tumors

  • Gene Amplification and Chromosome Abnormalities
  • Amplification of c-myc
  • New Members of the myc Gene Family
  • Amplification of erbB and erbB-2
  • Other Amplified Oncogenes
  • Summary
  • Chapter 9: Retinoblastoma and the Discovery of Tumor Suppressor Genes

  • Somatic Cell Hybridization
  • Inherited and Sporadic Retinoblastoma
  • Mapping the Retinoblastoma Gene
  • The Retinoblastoma Gene is Recessive at the Cellular Level
  • Molecular Cloning of the Rb Gene
  • Role of the Rb Gene in Other Neoplasms
  • Summary
  • Chapter 10: Tumor Suppressor Genes in Human Neoplasms

  • The p53 Gene
  • Identification of Additional Tumor Suppressor Genes in Colorectal Carcinomas
  • Tumor Suppressor Genes in Other Inherited Cancers
  • Candidates for Additional Tumor Suppressors
  • Summary
  • Chapter 11: Role of Oncogenes and Tumor Suppressor Genes in the Pathogenesis of Neoplasms

  • Biological Activities of Oncogenes in Vitro
  • Induction of Neoplasms by Oncogenes in Vivo
  • Oncogenes and Tumor Suppressor Genes in Tumors Induced by Chemical Carcinogens
  • Oncogenes and Tumor Suppressor Genes in Development of Human Neoplasms
  • Summary
  • Part: IV Functions of Oncogenes and Tumor Suppressor Genes

    Chapter 12: Oncogenes and Growth Factors

  • Platelet-Derived Growth Factor and the sis Oncogene
  • A Family of Oncogenes Related to Fibroblast Growth Factors
  • The wnt Gene Family
  • Transforming Activity of Epidermal Growth Factor and TGF-α
  • Hematopoietic Growth Factors as Oncogenes
  • Summary
  • Chapter 13: Protein-Tyrosine Kinases and Growth Factor Receptors

  • Lessons from Src: Protein-Tyrosine Kinases
  • Growth Factor Receptors: Protein-Tyrosine Kinases and Oncogenes
  • Nonreceptor Protein-Tyrosine Kinases
  • Oncogenes Derived from Nontyrosine Kinase Receptors
  • Summary
  • Chapter 14: Guanine Nucleotide Binding Proteins G Proteins

  • Similarities between Ras and the G Proteins
  • Proteins that Regulate Ras
  • Targets of Ras
  • Summary
  • Chapter 15: Protein-Serine/Threonine Kinases

  • The raf Oncogene Family
  • The Protein Kinase C Family
  • The mos Oncogene
  • Other Protein-Serine/Threonine Kinase Oncogenes
  • Summary
  • Chapter 16: Transcription Factors

  • Oncogenes and Steroid Hormone Receptors
  • The Jun and Fos Families: Components of Transcription Factor AP-1
  • The Myc Family
  • Other Oncogene Transcription Factors
  • Tumor Suppressor Gene Products
  • Summary
  • Chapter 17: Pathways of Mitogenic Signal Transduction

  • Receptor Tyrosine Kinases and Their Targets
  • Ras Activation
  • The Raf Protein-Serine/Threonine Kinase
  • The MAP Kinase Pathway
  • Transcription Factors and Alterations in Gene Expression
  • Summary
  • Chapter 18: Regulation of the Cell Cycle

  • Cyclins and Cyclin-Dependent Kinases
  • Cyclin D: A Proto-oncogene Inducible by Growth Factors
  • Cell Cycle Regulation of Rb
  • p53 and MTS1: Tumor Suppressors that Regulate Cdks
  • Role of p53 in Cell Cycle Arrest and Apoptosis Induced by DNA Damage
  • Summary
  • Chapter 19: Development, Differentiation, and Programmed Cell Death

  • Proto-oncogenes in Meiosis and Early Embryo Development
  • Role of the Ras/Raf Pathway in Development of Drosophila and C. elegans
  • Proto-oncogenes in Neuronal Differentiation
  • Developmental Roles of Other Proto-oncogenes
  • The bcl-2 Oncogene and Programmed Cell Death
  • Summary
  • Part: V Clinical Applications

    Chapter 20: New Prospects for Cancer Prevention and Treatment

  • Identification of Individuals with Inherited Susceptibilities to Cancer
  • Role of Oncogenes in Cancer Diagnosis
  • Development of Drugs Targeted against Oncogenes
  • Summary
  • Glossary



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