Pharmacogenomics in Drug Discovery and Development

Qing Yan
Release at: 2014
Pages: 731
Second Edition
File Size: 8 MB
File Type: pdf
Language: English

Description of Pharmacogenomics in Drug Discovery and Development

Pharmacogenomics is considered the future of drug therapy. It is a rapidly growing area in the recognition of the necessity of personalized medicine, a medicine that deals with the complexity of the human body. Because of the diversity of patients’ biological backgrounds, the same disease may be caused by genetic variations in different people, who will respond differently to the same drug. Such situations require individualized treatment that avoids adverse drug responses and ensures the best possible results. 

The evolution of biomedicine represents by pharmacogenomics developments from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. The transformation brings by pharmacogenomics from simple disease treatment to accurate prediction and effective prevention. For the drug discovery and development industry, pharmacogenomics is useful in identifying drug targets to obtain the optimal drug effi cacy for specifi c patient groups.

Content of Pharmacogenomics in Drug Discovery and Development


1 From Pharmacogenomics and Systems Biology to Personalized Care:
A Framework of Systems and Dynamical Medicine   3
Qing Yan

2 Translational Bioinformatics Approaches for Systems
and Dynamical Medicine   . . 19
Qing Yan

3 Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers
of Drug Response . 35
Grant P. Parnelland David R. Booth

4 Diagnostic Procedures for Paraffin-Embedded Tissues Analysis
in Pharmacogenomic Studies  . . 45
Raffaele Palmirotta, Maria Laura De Marchis, Giorgia Ludovici,
Patrizia Ferroni, Pasquale Abete, Fiorella Guadagni,
and David Della-Morte

5 Approach to Clinical and Genetic Characterization
of Statin-Induced Myopathy   . . 67
QiPing Feng

6 Pharmacogenetics of Membrane Transporters: A Review
of Current Approaches91
Tristan M. Sissung, Andrew K. L. Goey, Ariel M. Ley,
Jonathan D. Strope,and William D. Figg

7 G Protein-Coupled Receptor Accessory Proteins and Signaling:
Pharmacogenomic Insights    121
Miles D. Thompson, David E. C. Cole, Pedro A. Jose,and Peter Chidiac

118 G Protein-Coupled Receptor Mutations and Human Genetic Disease   . 153
Miles D. Thompson, Geoffrey N. Hendy, Maire E. Percy,
Daniel G. Bichet,and David E. C. Cole

9 Pharmacogenetics of the G Protein-Coupled Receptors 189
Miles D. Thompson, David E.C. Cole, Valerie Capra,
Katherine A. Siminovitch , G. Enrico Rovati , W. McIntyre Burnham ,
and Brinda K. Rana


10 Pharmacogenomics of Heart Failure . . 245
Anastasios Lymperopoulosand Faren French

11 Pharmacogenomics in the Development and Characterization
of Atheroprotective Drugs    259
Efi Valanti, Alexandros Tsompanidis,and Despina Sanoudou

12 Management of Side Effects in the Personalized Medicine Era:
Chemotherapy-Induced Peripheral Neuropathy   301
Paola Albertiand G. Cavaletti

13 Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic
Strategies for Drug Development  . 323
Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas,
Iván Tellado,and Juan C. Carril

14 Pharmacogenetics of Antipsychotic Treatment in Schizophrenia    . . 557
Jennie G. Pougetand Daniel J. Müller

15 Pharmacogenetics of Addiction Therapy. . 589
David A. Nielsen, Ellen M. Nielsen, Teja Dasari,
and Catherine J. Spellicy

16 Pharmacogenetics in Rheumatoid Arthritis625
Deepali Sen, Jisna R. Paul,and Prabha Ranganathan

17 Pharmacogenomics of Osteoporotic Fractures    . 661
José A. Rianchoand Flor M. Pérez-Campo

18 Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine   . 671
Barkur S. Shastry

19 Pharmacogenomics in Children  687
Michael Rieder

Index  709

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