Molecular Genetics of Recombination (PDF)

Molecular Genetics of Recombination

Author:
Andrés Aguilera & Rodney Rothstein
Release at: 2007
Pages: 536
Edition:
First Edition
File Size: 19 MB
File Type: pdf
Language: English




Description of Molecular Genetics of Recombination (PDF)

Molecular Genetics of Recombination by Andrés Aguilera & Rodney Rothstein is a great book for study Genetics available in (eBook) PDF download. Genetic recombination is an important process involved in shaping the genetic make up of progeny. Initially, genetic recombination studies focused on its relevance to sexual reproduction, including conjugation in bacteria and meiosis in eukaryotes. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells. It plays a critical role in preserving the integrity of the genome by mediating the repair of DNA damage, which can occur during normal cellular metabolism as a result of oxidative stress, transcription, replication fork stalling or breakdown, or after the exposure to DNA damaging agents.

Until recently, much of our knowledge on the mechanisms of genetic recombination has come from studies of prokaryotic and simple eukaryotic fungal systems. However, these studies have now been significantly extended to mammals, such that a comparative picture of the general factors and mechanisms of genetic recombination is beginning to emerge. Detailed genetic and biochemical studies have led to the isolation and characterization of many of the recombination-repair proteins in E. coli and S. cerevisiae, which in turn has led to the identification of homologues in human cells. The link between recombination defects and recombination proteins in a number of tumors as well as in human hereditary syndromes makes genetic recombination a cellular process of key importance not only in basic biology but also in biomedical studies.

Molecular Genetics of Recombination book is organized with 17 chapters written by active, qualified researchers on each topic. The chapters cover genetic recombination from both a historical and a conceptual perspective. Each chapter contains an introduction followed by an in-depth and up-to-date analysis of the current state of knowledge on its subject. In addition, the chapters were conceived and written autonomously, so that they can be read independently of the rest, even though this results in some repetitiveness of the basic concepts.




Content of Molecular Genetics of Recombination (PDF)


Chapter 1: Genetics of recombination in the model bacterium Escherichia coli

Chapter 2: Homologous recombination in low dC + dG Gram-positive bacteria

Chapter 3: The bacterial RecA protein: structure, function, and regulation

Chapter 4: Biochemistry of eukaryotic homologous recombination

Chapter 5: DNA helicases in recombination

Chapter 6: Holliday junction resolution

Chapter 7: Replication forks and replication checkpoints in repair

Chapter 8: Sister chromatid recombination

Chapter 9: Mating-type switching in S. pombe

Chapter 10: Multiple mechanisms of repairing meganuclease-induced double-strand DNA breaks in budding yeast

Chapter 11: The cell biology of mitotic recombination in Saccharomyces cerevisiae

Chapter 12: The cell biology of homologous recombination

Chapter 13: BRCA2: safeguarding the genome through homologous recombination

Chapter 14: Meiotic recombination

Chapter 15: Site-specific recombination

Chapter 16: V(D)J recombination: mechanism and consequences

Chapter 17: Nonhomologous end-joining: mechanisms, conservation and relationship to illegitimate recombination

Index

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