Molecular Biology of the Gene

Molecular Biology
 
Author:
James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick
Publisher: Benjamin Cummings
ISBN No: 978-0321-7-6243-6
Release at: 2013
Pages: 912
Edition:
Seventh Edition
File Size: 72 MB
File Type: pdf
Language: English



Description of Molecular Biology of the Gene


This MOLECULAR BIOLOGY OF THE GENE Book appears in this, it is Seventh edition, on the 60th anniversary of the discovery of the structure of DNA in 1953, an occasion celebrated by our cover design. The double-helical structure of DNA, held together by specific pairing between the bases on the two strands, has become one of the iconic images of science. After the end of the century, that image had in turn given way to the double helix. 

The field of molecular biology as we understand it today was born out of the discovery of the DNA structure and the agenda for research that structure immediately provided. The paper by Crick-Watson proposing the famous double helix sentence: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.

Content of Molecular Biology of the Gene



PART 1 HISTORY, 1

1 The Mendelian View of the World, 5 

2 Nucleic Acids Convey Genetic Information, 21

PART 2 STRUCTURE AND STUDY OF MACRO-MOLECULES, 45

3 The Importance of Weak and Strong Chemical Bonds, 51 

4 The Structure of DNA, 77 

5 The Structure and Versatility of RNA, 107 

6 The Structure of Proteins, 121 

7 Techniques of Molecular Biology, 147

PART 3 MAINTENANCE OF THE GENOME, 193

8 Genome Structure, Chromatin, and the Nucleosome, 199 

9 The Replication of DNA, 257 

10 The Mutability and Repair of DNA, 313 

11 Homologous Recombination at the Molecular Level, 341 

12 Site-Specific Recombination and Transposition of DNA, 377

PART 4 EXPRESSION OF THE GENOME, 423

13 Mechanisms of Transcription, 429 

14 RNA Splicing, 467 

15 Translation, 509 

16 The Genetic Code, 573 

17 The Origin and Early Evolution of Life, 593

PART 5 REGULATION, 609

18 Transcriptional Regulation in Prokaryotes, 615 

19 Transcriptional Regulation in Eukaryotes, 657 

20 Regulatory RNAs, 701 

21 Gene Regulation in Development and Evolution, 733 

22 Systems Biology, 775

PART 6 APPENDICES, 793

1 Model Organisms, 797 2 Answers, 831

Index, 845

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