| Author: |
James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick
|
| Release at: | 2013 |
| Pages: | 912 |
| Edition: |
Seventh Edition
|
| File Size: | 72 MB |
| File Type: | |
| Language: | English |
Description of Molecular Biology of the Gene
This MOLECULAR BIOLOGY OF THE GENE Book appears in this, it is Seventh edition, on the 60th anniversary of the discovery of the structure of DNA in 1953, an occasion celebrated by our cover design. The double-helical structure of DNA, held together by specific pairing between the bases on the two strands, has become one of the iconic images of science. After the end of the century, that image had in turn given way to the double helix.
The field of molecular biology as we understand it today was born out of the discovery of the DNA structure and the agenda for research that structure immediately provided. The paper by Crick-Watson proposing the famous double helix sentence: “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
Content of Molecular Biology of the Gene
PART 1 HISTORY, 1
1 The Mendelian View of the World, 5
2 Nucleic Acids Convey Genetic Information, 21
PART 2 STRUCTURE AND STUDY OF MACRO-MOLECULES, 45
3 The Importance of Weak and Strong Chemical Bonds, 51
4 The Structure of DNA, 77
5 The Structure and Versatility of RNA, 107
6 The Structure of Proteins, 121
7 Techniques of Molecular Biology, 147
PART 3 MAINTENANCE OF THE GENOME, 193
8 Genome Structure, Chromatin, and the Nucleosome, 199
9 The Replication of DNA, 257
10 The Mutability and Repair of DNA, 313
11 Homologous Recombination at the Molecular Level, 341
12 Site-Specific Recombination and Transposition of DNA, 377
PART 4 EXPRESSION OF THE GENOME, 423
13 Mechanisms of Transcription, 429
14 RNA Splicing, 467
15 Translation, 509
16 The Genetic Code, 573
17 The Origin and Early Evolution of Life, 593
PART 5 REGULATION, 609
18 Transcriptional Regulation in Prokaryotes, 615
19 Transcriptional Regulation in Eukaryotes, 657
20 Regulatory RNAs, 701
21 Gene Regulation in Development and Evolution, 733
22 Systems Biology, 775
PART 6 APPENDICES, 793
1 Model Organisms, 797 2 Answers, 831
Index, 845
1 The Mendelian View of the World, 5
2 Nucleic Acids Convey Genetic Information, 21
PART 2 STRUCTURE AND STUDY OF MACRO-MOLECULES, 45
3 The Importance of Weak and Strong Chemical Bonds, 51
4 The Structure of DNA, 77
5 The Structure and Versatility of RNA, 107
6 The Structure of Proteins, 121
7 Techniques of Molecular Biology, 147
PART 3 MAINTENANCE OF THE GENOME, 193
8 Genome Structure, Chromatin, and the Nucleosome, 199
9 The Replication of DNA, 257
10 The Mutability and Repair of DNA, 313
11 Homologous Recombination at the Molecular Level, 341
12 Site-Specific Recombination and Transposition of DNA, 377
PART 4 EXPRESSION OF THE GENOME, 423
13 Mechanisms of Transcription, 429
14 RNA Splicing, 467
15 Translation, 509
16 The Genetic Code, 573
17 The Origin and Early Evolution of Life, 593
PART 5 REGULATION, 609
18 Transcriptional Regulation in Prokaryotes, 615
19 Transcriptional Regulation in Eukaryotes, 657
20 Regulatory RNAs, 701
21 Gene Regulation in Development and Evolution, 733
22 Systems Biology, 775
PART 6 APPENDICES, 793
1 Model Organisms, 797 2 Answers, 831
Index, 845
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