Enzybiotics by Tomas G. Villa (PDF)

Enybiotics
 
Author:
Tomas G. Villa & Patricia Veiga-Crespo
Release at: 2010
Pages: 297
Edition:
1st Edition/Antibiotic Enzymes as 
Drugs and Therapeutics
File Size: 2 MB
File Type: pdf
Language: English


Description of Enybiotics Antibiotic Enzymes as Drugs and Therapeutics


Enzybiotics Antibiotic Enzymes as Drugs and Therapeutics written by Tomas G. Villa ebook for enzymes study in (PDF) to get a free printable download. The writing of a preface on an old-yet-new subject, such as the one in this book, is always a difficult task. It is common knowledge that the discovery of penicillin, and subsequently the rest of the antibiotics, has probably been one of the most important scientific contributions to civilization. By saving millions of lives, antibiotics automatically increased the half-life of mankind, thus allowing scientists to give their best to society for 20 to 30 additional years.

It is also common knowledge that resistance to antibiotics is a constant possibility and unfortunately something to be considered every time a new antibiotic goes on the market. Because of this, and because the discovery and design of new antibiotics becomes more and more difficult every year, society, through the work of several worldwide research groups, is looking into the use of what one of us (Dr. Vincent Fischetti) has termed “enzybiotics” (the result of blending the words “enzymes” and “antibiotics”), for treating bacterial and fungal diseases, either alone or in combination with antibiotics.

The book starts with four chapters in which the potential, advantages, and phylogeny of enzybiotics are reviewed. Then, the new ways of controlling infections by Gram-negative bacteria and an updated view of bacteriophage Hollins are presented. After a review of anti- staphylococcal lytic enzymes, the book goes on to discuss membrane-targeted enzybiotics, as well as the design of phage cocktails for current therapy. Finally, the last two chapters deal respectively with the novel methods to identify new enzybiotics and the use of modified phages to induce suicide in bacteria.

Content of Enybiotics Antibiotic Enzymes as Drugs and Therapeutics



1 ENZYBIOTICS & THEIR POTENTIAL APPLICATIONS IN MEDICINE 1
Jan Borysowski and Andrzej Gorski

2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS 27
Patricia Veiga-Crespo and Tomas G. Villa

3 ENZYBIOTICS AS TARGET BACTERIA KILLERS 59
Juan C. Alonso and Marcelo E. Tolmasky

4 PHYLOGENY OF ENZYBIOTICS 75
Patricia Veiga-Crespo and Tomas G. Villa

5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC 107
Vincent A. Fischetti

6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANE-DISRUPTING ACTIVITY 123
María Gasset

7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES 149
Jan Borysowski and Andrzej Gorski

8 MEMBRANE-TARGETED ENZYBIOTICS 173
María Gasset

9 PHAGE COCKTAILS DESIGN FOR THERAPY FROM A HOST RANGE POINT OF VIEW 199
Lawrence D. Goodridge

10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE 219
Jonathan E. Schmitz, Raymond Schuch, and Vincent A. Fischetti

11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIA 253
Lawrence D. Goodridge

CONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS 269
Patricia Veiga-Crespo and Tomas G. Villa

INDEX 279


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