Antiviral Agents, Vaccines, and Immunotherapies (PDF)

Antiviral Agents, Vaccines, and Immunotherapies
 
Author:
Stephen K. Tyring
Release at: 2005
Pages: 438
Edition:
1st Edition
File Size: 8 MB
File Type: pdf
Language: English


Description of Antiviral Agents, Vaccines, and Immunotherapies


Antiviral Agents, Vaccines, and Immunotherapies written by Stephen K. Tyring is a great book for virology infection study to get in (PDF) free download. The antiviral drug development is still in its infancy with progressive and rapid changes milestones encountered almost daily. By the time these Antiviral Agents, Vaccines, and Immunotherapies book is distributed, new drugs may have already been added. This antiretroviral drug is particularly true, which seems to be exponentially growing in number to the casual observer trying to keep abreast of recent advances in this field. As these Antiviral Agents, Vaccines, and Immunotherapies book is going to press, the U.S. Drug Administration and Food granted accelerated approval of Truvada and Epzicom. Epzicom is a fixed-dose combination of the antiretroviral drugs Ziagen like abacavir sulfate and Epivir like lamivudine. Truvada is a fixed-dose combination of Viread (tenofovir disoproxil fumarate) and Emtriva (emtricitabine). In keeping pace with these advances, the Antiviral Agents, Vaccines, and Immunotherapies book will survey the latest in antiretroviral drugs, general antiviral therapies, the antiviral vaccines, and immunotherapies used for treatment, and prophylaxis of viral infections.

Antiviral Agents, Vaccines, and Immunotherapies book begin with a review of the current state of the discussion and antiviral management (prophylaxis and therapy)of the challenges for the future. The second chapter of Antiviral Agents, Vaccines, and Immunotherapies discuss the major categories as well as the indications, adverse reactions, and drug interactions of each specific medication of the antiretroviral drugs. Chapter Three delves into the treatments available for other viral infections, such as herpes simplex virus, varicella-zoster virus, cytomegalovirus, chronic viral hepatitis, human papillomavirus, and others. The Antiviral Agents, Vaccines, and Immunotherapies book then conclude with a discussion of the vaccines that are currently available and being developed and gives an overview of the use of monoclonal antibodies and immunoglobulins for antiviral therapy.


Content of Antiviral Agents, Vaccines, and Immunotherapies



Chapter 1. Introduction. 1
References. 22

Chapter 2. Treat Human Immunodeficiency Virus Infections by Antiretroviral Drugs. 25
Introduction. 25
Human Immunodeficiency Virus. 27
Nucleoside Reverse Transcriptase Inhibitors. 39
Zidovudine [AZT] (Retrovir). 39
Didanosine[ddI] (Videx). 42
Stavudine [d4T] (Zerit). 44
Zalcitabine [ddc] (Hivid). 46
Lamivudine [3TC] (Epivir). 48
Abacavir [ABC] (Ziagen). 50
Emtricitabine (Emtriva, Coviracil, FTC). 52
Non-Nucleoside Reverse Transcriptase Inhibitors. 53
Nevirapine [NVP] (Viramune). 54
Delavirdine [DLV] (Rescriptor). 56
Efavirenz [EFV] (Sustiva). 59
Nucleotide Reverse Transcriptase Inhibitors. 62
Tenofovir Disproxil Fumarate (Viread). 62
HIV Protease Inhibitors. 65
Saquinavir [SQV] (Invirase: Hard Gel; Fortovase: Soft Gel). 67
Ritonavir [RTV] (Norvir). 68
Indinavir [IDV] (Crixivan). 71
Nelfinavir [NFV] (Viracept). 75
Amprenavir [APV] (Agenerase). 77
Fosamprenavir (Lexiva, GW 433908). 80
Atazanavir (Reyataz, BMS-232632). 83
Lopinavir + Ritonavir [ABT-378/r] (Kaletra). 84
Fusion Inhibitors. 85
Enfuvirtide (ENF, T-20, Pentasufide, Fuzeon). 86
Investigational Drugs. 88
Conclusion. 89
References. 90

Chapter 3. General (Non-Antiretroviral) Antiviral Drugs  123
Introduction. 123
Viral Infections Other than HIV. 126
Herpes Simplex Virus (HSV-1 and -2). 126
Varicella-Zoster Virus (VZV). 131
Epstein-Barr Virus (EBV). 132
Cytomegalovirus (CMV). 133
Human Herpesvirus 8 (HHV-8). 135
Human Papillomavirus (HPV). 135
Molluscum Contagiosum Virus (MCV) and other Poxviruses. 137
Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV). 139
Influenza Virus. 140
Respiratory Syncytial Virus (RSV). 142
Rhinovirus. 142
Nucleoside Analogs. 143
Acyclovir. 143
Valacyclovir. 154
Famciclovir. 160
Penciclovir. 166
Ganciclovir. 169
Valganciclovir. 174
Ribavirin. 178
Nucleotide Analogs. 184
Cidofovir. 184
Adefovir. 190
Antisense Drugs. 195
Fomivirsen. 196
Topical Immune Modulators. 199
Imiquimod. 199
Interferon-Alpha and Combinations. 204
Introduction. 204
Interferon-Alpha. 205
PEG-Interferon. 210
Ribavirin and Interferon-Alpha. 213
Ion Channel Function Inhibitors of M2 Proteins and Neuraminidase Inhibitors. 216
Amantadine. 217
Rimantadine. 224
Zanamivir. 226
Oseltamivir. 230
Pyrimidines. 235
Trifluridine (1% Ophthalmic Solution). 235
Other Antivirals and Medications. 238
Foscarnet. 238
Docosanol. 245
Implications for New Antiviral Agents. 246
References. 246

Chapter 4. Vaccines and Immunotherapies. 291
Introduction. 291
Smallpox and Other Poxviruses. 296
Smallpox. 296
New Vaccines for Poxviruses Currently Under Investigation. 300
Measles, Mumps, and Rubella Vaccines. 300
Measles. 312
Mumps. 313
Rubella. 314
Varicella-Zoster Virus Vaccine. 315
Influenza Virus Vaccine. 318
New Developments in Influenza Vaccines. 321
Hepatitis A Virus Vaccine. 321
Hepatitis B Virus Vaccine. 323
Rabies Virus Vaccine. 326
Recent and Continuing Developments in Rabies Vaccines. 330
Poliovirus Vaccines. 331
Yellow Fever Virus Vaccine. 336
Japanese Encephalitis Virus Vaccine. 339
Adenovirus Vaccines. 341
Investigational Vaccines. 342
Rotavirus. 342
Varicella-Zoster Virus  Vaccine. 345
Human Immunodeficiency Virus  Vaccine. 349
Herpes Simplex Virus Vaccine. 352
Human Papillomavirus Vaccine. 354
Cytomegalovirus Vaccine. 355
Respiratory Syncytial Virus  Vaccine. 357
Parainfluenza Virus Vaccine. 359
Other Vaccines. 361
Immunoglobulins. 362
Monoclonal Antibodies. 367
Conclusion. 368
References. 370

Index. 409

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